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Objective To investigate whether psychosocial risk factors such as parental separation, parental unemployment and. experiences of sexual abuse are associated with adolescent depression, and whether shaming, experiences (defined as experiences of being degraded, or ridiculed by others) may account for such an association. Method A total of 5048 Swedish adolescents answered the Survey of Adolescent Life in Vestmanland 2004 (SALVe-2004) during classhours. The survey included questions about depressive symptoms, parental separation, parental unemployment and experiences of sexual abuse. Results The psychosocial risk factors studied were all associated with depression, but several of these associations became non-significant when a factor for shaming experiences was entered into the models. The explained variance for depression furthermore increased from approximately 4-7% to 17-20% when shame was included. Conclusion Shaming experiences may mediate part of the association between psychosocial risk factors and depression. These findings may have important implications for the understanding of psychotherapeutic treatment of the effects of risk factors in depressed patients.