Previous empirical research on the industrial use and usability of methodologies and tools for product innovation is often based on national samples, and generally focuses on a few select industry sectors and typically lacks a perspective on methodologies as supportive instruments for the product innovation work process. Moreover, even if some studies recognise the problems with low company methodology awareness and use, the underlying causes remain unexplained. In a survey mode of inquiry involving informants in 19 global manufacturing companies in six sectors of the process industries, this study explores use and usability of methodologies in the development of non-assembled products in the process industries. While the findings demonstrate a rather scarce use of innovation methodologies, when they are used case-company informants not only report a high degree of usability but also recommend that all introduced methodologies should be included in an enhanced product innovation work process. The discussion advocates that an overarching strategy for methodology use should be institutionalised by company R&D management, including a "methodology tool-box"of select methodologies, and further facilitated by trained methodology experts as "ambassadors".