Background: End-of-life care is characterized by relieving patients’ suffering in the end-oflife care. Previous research suggests that patients can experience both joy and sorrow when inthe end-of-life stage. When cared for by nurses, they may feel safe but also overlooked. Aim:To describe nurses' experiences of caring for patients at the end of life. Method: A generalliterature review based on 13 articles, including six qualitative, six quantitative, and onemixed-method study. Results: Three themes emerged; The relationship with the patient,The significance of external factors and significance of internal factors. A good relationshipbetween nurses and patients was essential for achieving quality care. Nurses experiencedemotional challenges when caring for patients. Team collaboration was seen as a crucialfactor, and nurses reported a lack of knowledge, experience and confidence in caring forpatients at the end of life. Conclusion: The need for education is great and would contributeto higher-quality end-of-life care.Keywords: end-of-life care, experience, knowledge, nurse, palliative care