In the evolving landscape of project management, the challenge of managing uncertainty is paramount, particularly in innovation and design projects where the unpredictable nature of activities often defies traditional project management methods. This study introduces a novel integration of game-based learning (GBL). The research explores how GBL can simulate real-world uncertainties and foster adaptive skills in managing the unforeseen variables characteristic of innovation projects. By engaging students in a master’s course, through game-based workshops, the study evaluates how these interactive experiences enhance their ability to navigate and manage project uncertainties effectively. Additionally, the paper examines the utility of the ISO56000-series in guiding these uncertain environments, exploring how it can be adapted to better support innovation-driven project management. Through this dual approach, the study aims to offer insights into blending structured project management frameworks with the flexible, exploratory nature required for successful innovation and design projects. The findings suggest that combining GBL with targeted standards can significantly mitigate uncertainty and enhance the innovative capacity within complex project environments.