Introduction: Studies on the association between work-family conflict and self-reported health are mostly cross-sectional;few studies have investigated the effect of education on this association. Objectives: To investigate association between work-family conflict,family-work conflict, lack of time for self-care and leisure due to family and work demands, and self-rated health trajectories, examining sexdifferences and the modifying effect of education on these associations. Methods: Data from active workers (women = 4,283; men = 3,851)from the three waves and annual follow-up (2008-2020) of the Longitudinal Study of Adult Health were analyzed using multinomial logisticmodels. Results: Work-family conflict, family-work conflict, and lack of time were associated with worse self-rated health trajectories in bothsexes. However, among women who reported a lack of time for self-care and leisure, education was a modifying factor. The odds of a fair orpoor self-reported health trajectory were higher among women with a high education level who reported a lack of time “sometimes” or “often”than in women with a low education level. Conclusions: Work-family conflict dimensions were associated with worse self-reported healthtrajectories among both women and men. Education only modified this effect among women.