For any real division algebra A of finite dimension greater than one, the signs of the determinants of left multiplication and right multiplication by an element a∈ A{set minus}{0} are shown to form an invariant of A, called its double sign. For each n ∈ {2, 4, 8}, the double sign causes the category of all n-dimensional realdivision algebras to decompose into four blocks. The structures of these blocks are closely related, and their relationship is made precise for a sample of full subcategories of.